Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Kisselburgh HM[original query] |
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Shiga toxin-producing Escherichia coli outbreaks in the United States, 20102017
Tack DM , Kisselburgh HM , Richardson LC , Geissler A , Griffin PM , Payne DC , Gleason BL . Microorganisms 2021 9 (7) Shiga toxin-producing Escherichia coli (STEC) cause illnesses ranging from mild diarrhea to ischemic colitis and hemolytic uremic syndrome (HUS); serogroup O157 is the most common cause. We describe the epidemiology and transmission routes for U.S. STEC outbreaks during 2010– 2017. Health departments reported 466 STEC outbreaks affecting 4769 persons; 459 outbreaks had a serogroup identified (330 O157, 124 non-O157, 5 both). Among these, 361 (77%) had a known transmission route: 200 foodborne (44% of O157 outbreaks, 41% of non-O157 outbreaks), 87 person-toperson (16%, 24%), 49 animal contact (11%, 9%), 20 water (4%, 5%), and 5 environmental contamination (2%, 0%). The most common food category implicated was vegetable row crops. The distribution of O157 and non-O157 outbreaks varied by age, sex, and severity. A significantly higher percentage of STEC O157 than non-O157 outbreaks were transmitted by beef (p = 0.02). STEC O157 outbreaks also had significantly higher rates of hospitalization and HUS (p < 0.001). © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Assessing the maximum size of annual foodborne outbreaks in the United States: An analysis of 1973-2016 outbreaks
Ebel ED , Williams MS , Ward-Gokhale LA , Kisselburgh HM . Microb Risk Anal 2019 12 20-26 Foodborne disease outbreaks are rare events that can be extremely costly in terms of public health as well as monetary losses for industry and government. These events can overwhelm the local public healthcare network and exceed the capacity of epidemiologists and local public health officials to investigate and manage the outbreak. Planning and allocation of sufficient resources requires an understanding of both the frequency and magnitude of large foodborne outbreaks. Describing these two characteristics is difficult because most statistical methods describe central tendencies of the phenomena under study. An exception is extreme value theory (EVT), which intends to estimate the size and frequency of adverse events as large as, or larger than, those previously observed. This study applies extreme value theory methods to foodborne disease outbreak data collected in the United States between 1973 and 2016. A brief summary of the data, including changes in the surveillance system and their effect on the outbreak data, is provided. Estimates of the outbreak size expected to be exceeded within time periods of 10, 20, 40 and 100 years, referred to as the return level, ranged from 2500 to 10,400. The estimated time period time between outbreaks (i.e., the return period) of at least 500, 5,000, 10,000 and 20,000 cases ranged from 1 to greater than 400 years. |
Pediatric botulism and use of equine botulinum antitoxin in children: A systematic review
Griese SE , Kisselburgh HM , Bartenfeld MT , Thomas E , Rao AK , Sobel J , Dziuban EJ . Clin Infect Dis 2017 66 S17-s29 Background: Botulism manifests with cranial nerve palsies and flaccid paralysis in children and adults. Botulism must be rapidly identified and treated; however, clinical presentation and treatment outcomes of noninfant botulism in children are not well described. Methods: We searched 12 databases for peer-reviewed and non-peer-reviewed reports with primary data on botulism in children (persons <18 years of age) or botulinum antitoxin administration to children. Reports underwent title and abstract screening and full text review. For each case, patient demographic, clinical, and outcome data were abstracted. Results: Of 7065 reports identified, 184 met inclusion criteria and described 360 pediatric botulism cases (79% confirmed, 21% probable) that occurred during 1929-2015 in 34 countries. Fifty-three percent were male; age ranged from 4 months to 17 years (median, 10 years). The most commonly reported signs and symptoms were dysphagia (53%), dysarthria (39%), and generalized weakness (37%). Inpatient length of stay ranged from 1 to 425 days (median, 24 days); 14% of cases required intensive care unit admission; 25% reported mechanical ventilation. Eighty-three (23%) children died. Median interval from illness onset to death was 1 day (range, 0-260 days). Among patients who received antitoxin (n = 193), 23 (12%) reported an adverse event, including rash, fever, serum sickness, and anaphylaxis. Relative risk of death among patients treated with antitoxin compared with patients not treated with antitoxin was 0.24 (95% confidence interval, .14-.40; P < .0001). Conclusions: Dysphagia and dysarthria were the most commonly reported cranial nerve symptoms in children with botulism; generalized weakness was described more than paralysis. Children who received antitoxin had better survival; serious adverse events were rare. Most deaths occurred early in the clinical course; therefore, botulism in children should be identified and treated rapidly. |
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